The Minutes of David Friedberg on aging https://minutesof.com/david-friedberg/on/aging/ Everything David Friedberg has said on aging: 13 verbatim quotes between February 2023 and July 2026, each with a timestamp and a link to the recording it… en Sun, 30 Aug 2026 16:22:42 +0000 Friedberg explains CML is the predominant aging molecule in extracellular matrix that nothing naturally breaks https://minutesof.com/q/156212e7-ec02-41a8-82bc-7becf2184ed0/ https://minutesof.com/q/156212e7-ec02-41a8-82bc-7becf2184ed0/ “CML is kind of the predominant molecule that that gets formed in this extracellular matrix that's driving aging, and nothing breaks it down. So these scientists set out to try and create an enzyme.” — All-In Podcast Sat, 18 Jul 2026 13:35:23 +0000 aging Friedberg reports that the enzyme eliminated 52 to 97% of CML from body proteins including collagen and hemogl https://minutesof.com/q/cae43f9a-938e-4b63-8fb0-ad54ba5d1730/ https://minutesof.com/q/cae43f9a-938e-4b63-8fb0-ad54ba5d1730/ “They started to test it on the proteins that we would find in our body, casine, collagen, retinal proteins, which are in your eye, hemoglobin, and they were able to get rid of 52 to 97% of the CML, just degraded away.” — All-In Podcast Sat, 18 Jul 2026 13:35:23 +0000 aging Friedberg describes scientists reversing skin age from over 70 to 31 by eliminating 55% of CML. https://minutesof.com/q/5c40ff71-2d72-472e-89cf-0f0fb1c2c8d9/ https://minutesof.com/q/5c40ff71-2d72-472e-89cf-0f0fb1c2c8d9/ “And they put this enzyme onto that skin, and they were able to eliminate 55% of the CML on the skin, basically reverse the skin's age down to the age of a 31 year old.” — All-In Podcast Sat, 18 Jul 2026 13:35:23 +0000 aging Friedberg emphasizes the enzyme worked on skin from patients over 70 years old. https://minutesof.com/q/0898d29c-679f-40d4-aba8-d3b7e335beac/ https://minutesof.com/q/0898d29c-679f-40d4-aba8-d3b7e335beac/ “This is from greater than 70 year old patients just by putting this enzyme on the skin.” — All-In Podcast Sat, 18 Jul 2026 13:35:23 +0000 aging Friedberg suggests the enzyme could be delivered simply as a topical skin cream. https://minutesof.com/q/93104798-0b6e-4b1c-8f18-1414615f447b/ https://minutesof.com/q/93104798-0b6e-4b1c-8f18-1414615f447b/ “If you could put this enzyme literally on your skin and have it absorb in cream?” — All-In Podcast Sat, 18 Jul 2026 13:35:23 +0000 aging Friedberg explains scientists created an enzyme to break down CML, the predominant aging molecule that nothing https://minutesof.com/q/20f44940-e647-4d52-969f-92e06cd256ee/ https://minutesof.com/q/20f44940-e647-4d52-969f-92e06cd256ee/ “CML is kind of the predominant molecule that gets formed in this extracellular matrix that's driving aging, and nothing breaks it down. So these scientists set out to try and create an enzyme.” — All-In Podcast Sat, 18 Jul 2026 00:54:40 +0000 aging Friedberg explains scientists created enzyme to break down CML using DNA programming where three letters code https://minutesof.com/q/8f2127c3-1a37-40cc-8def-477224acdd2b/ https://minutesof.com/q/8f2127c3-1a37-40cc-8def-477224acdd2b/ “An enzyme is a protein that breaks something down, that can break down CML. And remember, a protein is just a series of amino acids, and those amino acids are programmed by DNA.” — All-In Podcast Sat, 18 Jul 2026 00:54:40 +0000 aging Friedberg reports the enzyme eliminated 52 to 97% of aging molecules in human body proteins after five optimiz https://minutesof.com/q/88482a72-91e1-4a5d-84ec-2cf1f9072038/ https://minutesof.com/q/88482a72-91e1-4a5d-84ec-2cf1f9072038/ “And they did this recursively five different cycles, and then eventually they tested it once they kinda gotten it breaking down the CML really well in a test tube.” — All-In Podcast Sat, 18 Jul 2026 00:54:40 +0000 aging Friedberg reports enzyme eliminated 55% of CML on elderly skin, reversing age markers from over 70 to 31 years https://minutesof.com/q/5830617a-b451-4787-bbdf-8394666b171c/ https://minutesof.com/q/5830617a-b451-4787-bbdf-8394666b171c/ “they took actual human skin from elderly patients that had donated their skin, and they put this enzyme onto that skin and they were able to eliminate 55% of the CML on the skin, which basically reversed the skin's age down to the age of a 31 year old. This is from greater than 70 year old patients,” — All-In Podcast Sat, 18 Jul 2026 00:54:40 +0000 aging Friedberg explains that partial application of Yamanaka factors can reverse aging in cells without converting https://minutesof.com/q/de2f5080-edaf-49e1-9db8-fccebea8f54d/ https://minutesof.com/q/de2f5080-edaf-49e1-9db8-fccebea8f54d/ “In 2016, another scientist published a series of papers showing that instead of putting a lot of those four proteins on the cell, you could put a small amount.” — Chris Williamson Mon, 13 Apr 2026 15:00:13 +0000 aging Friedberg says dysfunctional mitochondria may be a key driver for cancers, Alzheimer's, Parkinson's, ALS, and https://minutesof.com/q/a12d6ca9-8d9a-4ee2-9a20-7a3c018f36f0/ https://minutesof.com/q/a12d6ca9-8d9a-4ee2-9a20-7a3c018f36f0/ “So every cell in our body gets its energy, which is what it uses to function from the mitochondria.” — All-In Podcast Wed, 23 Apr 2025 20:53:33 +0000 aging Friedberg says Columbia's first brain mitochondria map suggests dysfunction drives memory loss and aging sympt https://minutesof.com/q/bde69020-bedf-48d9-916a-ea1518161341/ https://minutesof.com/q/bde69020-bedf-48d9-916a-ea1518161341/ “The second paper was done, last month out of Columbia University, and this was the first mapping of the mitochondria in the human brain.” — All-In Podcast Wed, 23 Apr 2025 20:53:33 +0000 aging Friedberg cites recent Harvard research showing aging may be driven by epigenome dysfunction rather than DNA m https://minutesof.com/q/da7eb94a-132d-482c-9d9f-19c8df5159ef/ https://minutesof.com/q/da7eb94a-132d-482c-9d9f-19c8df5159ef/ “And increasingly, there's evidence as published a few weeks ago in two different papers, including one out of led by a team out of Harvard, that it may be dysfunctions not in the genome and the DNA, but actually dysfunctions in the epigenome, which is the molecules that sit on the DNA.” — Dr Brian Keating Thu, 09 Feb 2023 18:00:09 +0000 aging