The Minutes of David Friedberg on biology https://minutesof.com/david-friedberg/on/biology/ Everything David Friedberg has said on biology: 13 verbatim quotes between March 2020 and July 2026, each with a timestamp and a link to the recording it… en Sun, 30 Aug 2026 16:22:42 +0000 Friedberg explains CML is the predominant aging molecule in extracellular matrix that nothing naturally breaks https://minutesof.com/q/156212e7-ec02-41a8-82bc-7becf2184ed0/ https://minutesof.com/q/156212e7-ec02-41a8-82bc-7becf2184ed0/ “CML is kind of the predominant molecule that that gets formed in this extracellular matrix that's driving aging, and nothing breaks it down. So these scientists set out to try and create an enzyme.” — All-In Podcast Sat, 18 Jul 2026 13:35:23 +0000 biology Friedberg reports that the enzyme eliminated 52 to 97% of CML from body proteins including collagen and hemogl https://minutesof.com/q/cae43f9a-938e-4b63-8fb0-ad54ba5d1730/ https://minutesof.com/q/cae43f9a-938e-4b63-8fb0-ad54ba5d1730/ “They started to test it on the proteins that we would find in our body, casine, collagen, retinal proteins, which are in your eye, hemoglobin, and they were able to get rid of 52 to 97% of the CML, just degraded away.” — All-In Podcast Sat, 18 Jul 2026 13:35:23 +0000 biology Friedberg emphasizes the enzyme worked on skin from patients over 70 years old. https://minutesof.com/q/0898d29c-679f-40d4-aba8-d3b7e335beac/ https://minutesof.com/q/0898d29c-679f-40d4-aba8-d3b7e335beac/ “This is from greater than 70 year old patients just by putting this enzyme on the skin.” — All-In Podcast Sat, 18 Jul 2026 13:35:23 +0000 biology Friedberg explains the breakthrough combines AlphaFold and directed evolution to create novel proteins not fou https://minutesof.com/q/1275756d-4b5f-4e1d-a795-f3c9affbc0e2/ https://minutesof.com/q/1275756d-4b5f-4e1d-a795-f3c9affbc0e2/ “And so it's kind of a groundbreaking demonstration of combination of alpha fold, what's called directed evolution, where you change the order of the DNA that changes the structure of the protein to test different proteins, do high throughput screening, and ultimately make a novel protein that doesn't exist in nature today” — All-In Podcast Sat, 18 Jul 2026 13:35:23 +0000 biology Friedberg explains scientists created an enzyme to break down CML, the predominant aging molecule that nothing https://minutesof.com/q/20f44940-e647-4d52-969f-92e06cd256ee/ https://minutesof.com/q/20f44940-e647-4d52-969f-92e06cd256ee/ “CML is kind of the predominant molecule that gets formed in this extracellular matrix that's driving aging, and nothing breaks it down. So these scientists set out to try and create an enzyme.” — All-In Podcast Sat, 18 Jul 2026 00:54:40 +0000 biology Friedberg explains scientists created enzyme to break down CML using DNA programming where three letters code https://minutesof.com/q/8f2127c3-1a37-40cc-8def-477224acdd2b/ https://minutesof.com/q/8f2127c3-1a37-40cc-8def-477224acdd2b/ “An enzyme is a protein that breaks something down, that can break down CML. And remember, a protein is just a series of amino acids, and those amino acids are programmed by DNA.” — All-In Podcast Sat, 18 Jul 2026 00:54:40 +0000 biology Friedberg explains that partial application of Yamanaka factors can reverse aging in cells without converting https://minutesof.com/q/de2f5080-edaf-49e1-9db8-fccebea8f54d/ https://minutesof.com/q/de2f5080-edaf-49e1-9db8-fccebea8f54d/ “In 2016, another scientist published a series of papers showing that instead of putting a lot of those four proteins on the cell, you could put a small amount.” — Chris Williamson Mon, 13 Apr 2026 15:00:13 +0000 biology Friedberg states there are more bacteria in the human gut than cells in the body with profound health effects. https://minutesof.com/q/a6b0a4cb-c99e-438c-9570-54e7fe9b3eed/ https://minutesof.com/q/a6b0a4cb-c99e-438c-9570-54e7fe9b3eed/ “So there's more bacteria living in our gut than there are cells in our body. The human gut, as you guys know, has all these bacteria that can have a profound effect on your health,” — Jill & Jenna Thu, 19 Mar 2026 09:00:12 +0000 biology Friedberg explains Ohalo's core idea: making sex cells carry complete DNA from both parents, which occurs spon https://minutesof.com/q/211728e3-185d-49b9-a68c-353ecafeacf7/ https://minutesof.com/q/211728e3-185d-49b9-a68c-353ecafeacf7/ “what would happen if we could get the sex cells to have all the DNA of the mother and all the DNA of the father, the complete genome?” — TED Tue, 25 Jun 2024 11:00:23 +0000 biology Friedberg notes DNA sequencing costs have fallen faster than Moore's Law over twenty years. https://minutesof.com/q/59c59dd6-3fa1-4c35-98db-497ee836adf7/ https://minutesof.com/q/59c59dd6-3fa1-4c35-98db-497ee836adf7/ “Yep. Now digital technologies have driven the cost down of DNA sequencing faster than Moore's Law in the past twenty years.” — Dr Brian Keating Thu, 09 Feb 2023 18:00:09 +0000 biology Friedberg states gut microbiome research has grown geometrically as DNA sequencing costs have dropped dramatic https://minutesof.com/q/c9526065-8ccd-4ece-8daf-790764abb157/ https://minutesof.com/q/c9526065-8ccd-4ece-8daf-790764abb157/ “So the number of papers on the gut biome has kind of grown geometrically last couple years.” — Dr Brian Keating Thu, 09 Feb 2023 18:00:09 +0000 biology Friedberg cites research showing 40-60% of people have T cell immunity from prior coronavirus exposure. https://minutesof.com/q/f5eccc64-d164-4c37-a90e-53264f2455cd/ https://minutesof.com/q/f5eccc64-d164-4c37-a90e-53264f2455cd/ “And the reason is that they've had other coronaviruses through a common cold and they've developed this immune response.” — All-In Podcast Thu, 21 May 2020 05:18:18 +0000 biology Friedberg invokes sirtuin genes that switch cells between growth and healing modes to advise startups. https://minutesof.com/q/82b372d6-072e-4b8d-85dd-816cb06b4fa4/ https://minutesof.com/q/82b372d6-072e-4b8d-85dd-816cb06b4fa4/ “And this is a time for everyone to activate their CIRT genes and stop focusing on growth and focus on healing.” — All-In Podcast Thu, 19 Mar 2020 01:16:53 +0000 biology