https://minutesof.com/on/aging/ Everyone on the record about aging: 15 verbatim quotes from 2 people, February 2023 to July 2026, in one chronology, each with a timestamp and a link to… en Mon, 31 Aug 2026 13:17:57 +0000 https://minutesof.com/q/93104798-0b6e-4b1c-8f18-1414615f447b/ https://minutesof.com/q/93104798-0b6e-4b1c-8f18-1414615f447b/ “If you could put this enzyme literally on your skin and have it absorb in cream?” — David Friedberg, All-In Podcast Sat, 18 Jul 2026 13:35:23 +0000 aging https://minutesof.com/q/0898d29c-679f-40d4-aba8-d3b7e335beac/ https://minutesof.com/q/0898d29c-679f-40d4-aba8-d3b7e335beac/ “This is from greater than 70 year old patients just by putting this enzyme on the skin.” — David Friedberg, All-In Podcast Sat, 18 Jul 2026 13:35:23 +0000 aging https://minutesof.com/q/5c40ff71-2d72-472e-89cf-0f0fb1c2c8d9/ https://minutesof.com/q/5c40ff71-2d72-472e-89cf-0f0fb1c2c8d9/ “And they put this enzyme onto that skin, and they were able to eliminate 55% of the CML on the skin, basically reverse the skin's age down to the age of a 31 year old.” — David Friedberg, All-In Podcast Sat, 18 Jul 2026 13:35:23 +0000 aging https://minutesof.com/q/cae43f9a-938e-4b63-8fb0-ad54ba5d1730/ https://minutesof.com/q/cae43f9a-938e-4b63-8fb0-ad54ba5d1730/ “They started to test it on the proteins that we would find in our body, casine, collagen, retinal proteins, which are in your eye, hemoglobin, and they were able to get rid of 52 to 97% of the CML, just degraded away.” — David Friedberg, All-In Podcast Sat, 18 Jul 2026 13:35:23 +0000 aging https://minutesof.com/q/156212e7-ec02-41a8-82bc-7becf2184ed0/ https://minutesof.com/q/156212e7-ec02-41a8-82bc-7becf2184ed0/ “CML is kind of the predominant molecule that that gets formed in this extracellular matrix that's driving aging, and nothing breaks it down. So these scientists set out to try and create an enzyme.” — David Friedberg, All-In Podcast Sat, 18 Jul 2026 13:35:23 +0000 aging https://minutesof.com/q/5830617a-b451-4787-bbdf-8394666b171c/ https://minutesof.com/q/5830617a-b451-4787-bbdf-8394666b171c/ “they took actual human skin from elderly patients that had donated their skin, and they put this enzyme onto that skin and they were able to eliminate 55% of the CML on the skin, which basically reversed the skin's age down to the age of a 31 year old. This is from greater than 70 year old patients,” — David Friedberg, All-In Podcast Sat, 18 Jul 2026 00:54:40 +0000 aging https://minutesof.com/q/88482a72-91e1-4a5d-84ec-2cf1f9072038/ https://minutesof.com/q/88482a72-91e1-4a5d-84ec-2cf1f9072038/ “And they did this recursively five different cycles, and then eventually they tested it once they kinda gotten it breaking down the CML really well in a test tube.” — David Friedberg, All-In Podcast Sat, 18 Jul 2026 00:54:40 +0000 aging https://minutesof.com/q/8f2127c3-1a37-40cc-8def-477224acdd2b/ https://minutesof.com/q/8f2127c3-1a37-40cc-8def-477224acdd2b/ “An enzyme is a protein that breaks something down, that can break down CML. And remember, a protein is just a series of amino acids, and those amino acids are programmed by DNA.” — David Friedberg, All-In Podcast Sat, 18 Jul 2026 00:54:40 +0000 aging https://minutesof.com/q/20f44940-e647-4d52-969f-92e06cd256ee/ https://minutesof.com/q/20f44940-e647-4d52-969f-92e06cd256ee/ “CML is kind of the predominant molecule that gets formed in this extracellular matrix that's driving aging, and nothing breaks it down. So these scientists set out to try and create an enzyme.” — David Friedberg, All-In Podcast Sat, 18 Jul 2026 00:54:40 +0000 aging https://minutesof.com/q/de2f5080-edaf-49e1-9db8-fccebea8f54d/ https://minutesof.com/q/de2f5080-edaf-49e1-9db8-fccebea8f54d/ “In 2016, another scientist published a series of papers showing that instead of putting a lot of those four proteins on the cell, you could put a small amount.” — David Friedberg, Chris Williamson Mon, 13 Apr 2026 15:00:13 +0000 aging https://minutesof.com/q/bde69020-bedf-48d9-916a-ea1518161341/ https://minutesof.com/q/bde69020-bedf-48d9-916a-ea1518161341/ “The second paper was done, last month out of Columbia University, and this was the first mapping of the mitochondria in the human brain.” — David Friedberg, All-In Podcast Wed, 23 Apr 2025 20:53:33 +0000 aging https://minutesof.com/q/a12d6ca9-8d9a-4ee2-9a20-7a3c018f36f0/ https://minutesof.com/q/a12d6ca9-8d9a-4ee2-9a20-7a3c018f36f0/ “So every cell in our body gets its energy, which is what it uses to function from the mitochondria.” — David Friedberg, All-In Podcast Wed, 23 Apr 2025 20:53:33 +0000 aging https://minutesof.com/q/43038c3e-931c-4be1-8516-0d5d485626b8/ https://minutesof.com/q/43038c3e-931c-4be1-8516-0d5d485626b8/ “The more people hang around Washington for a very long period of time, they just learn how to influence it.” — Bill Gurley, Invest Like the Best Tue, 23 Apr 2024 08:00:00 +0000 aging https://minutesof.com/q/da7eb94a-132d-482c-9d9f-19c8df5159ef/ https://minutesof.com/q/da7eb94a-132d-482c-9d9f-19c8df5159ef/ “And increasingly, there's evidence as published a few weeks ago in two different papers, including one out of led by a team out of Harvard, that it may be dysfunctions not in the genome and the DNA, but actually dysfunctions in the epigenome, which is the molecules that sit on the DNA.” — David Friedberg, Dr Brian Keating Thu, 09 Feb 2023 18:00:09 +0000 aging https://minutesof.com/q/b8ff0788-4f5e-40d0-bd86-830f92406d7a/ https://minutesof.com/q/b8ff0788-4f5e-40d0-bd86-830f92406d7a/ “They raised about $3,000,000,000 in startup funding, and they're pursuing this kind of epigenetic partial reprogramming of cells to make them more youthful.” — David Friedberg, Dr Brian Keating Thu, 09 Feb 2023 18:00:09 +0000 aging