Friedberg explains the breakthrough combines AlphaFold and directed evolution to create novel proteins not found in nature.
“And so it's kind of a groundbreaking demonstration of combination of alpha fold, what's called directed evolution, where you change the order of the DNA that changes the structure of the protein to test different proteins, do high throughput screening, and ultimately make a novel protein that doesn't exist in nature today”
Friedberg describes how researchers used AlphaFold to design an anti-aging protein, then created thousands of variants to optimize it.
“And they made hundreds and then thousands of variants of it to measure activity, which is how good is it at breaking down the CML.”
Friedberg describes breakthrough combining AlphaFold and directed evolution to create novel protein not existing in nature for age reversal.
“groundbreaking demonstration of combination of alpha fold, what's called directed evolution, where you change the order of the DNA that changes the structure of the protein to test different proteins, do high throughput screening, and ultimately make a novel protein that doesn't exist in nature today”